Jacob L Edmondson

Researcher

UAMS

Last publication 2026 Last refreshed 2026-05-16

faculty

3 h-index 14 pubs 126 cited

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OverviewAI-generated summary

Jacob L. Edmondson's research focuses on the molecular mechanisms underlying cancer development and progression, with a particular emphasis on immune responses to tumors. His recent publications investigate the role of specific proteins and signaling pathways, such as NIMA-related kinases (NEK2), ATF6, and PCK2, in tumorigenesis and the efficacy of cancer therapies, including immune checkpoint blockade (ICB) and T-cell function. Edmondson has also explored proteome turnover dynamics to identify factors influencing T-cell persistence and exhaustion during anti-cancer immunity.

His work involves studying gene expression regulation in neoplastic cells and identifying potential therapeutic targets, such as protein kinase inhibitors. Edmondson collaborates with researchers at the University of Arkansas for Medical Sciences, including Brian Koss, Daniel Fil, Megan R. Reed, and Billie Heflin, with whom he has co-authored multiple publications. His scholarship metrics include an h-index of 3, with 13 total publications and 123 citations.

Metrics

h-index: 3
Publications: 14
Citations: 126

Selected Publications

691 ATF6 activation promotes ICB response in melanoma (2025)

DOI OpenAlex
762 CD28 costimulation induces PCK2 to support T cell effector function in metabolically hostile environments (2025)

DOI OpenAlex
277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion (2025)

DOI OpenAlex
Comprehensive Analysis of Proteome Turnover Dynamics During T Cell Exhaustion (2025)

DOI OpenAlex
EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma (2025)

1 citation DOI OpenAlex
1132 Enhancing melanoma therapy efficacy by protecting EZH2 activity in T cells (2024)

DOI OpenAlex
538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response (2024)

DOI OpenAlex
319 Comprehensive analysis of proteome turnover dynamics during T cell exhaustion (2024)

DOI OpenAlex
932 Defining the role for PCK2 in T-cell metabolic plasticity (2024)

DOI OpenAlex
Role of NEK2 in tumorigenesis and tumor progression (2024)

21 citations DOI OpenAlex
Abstract 584: Synergistic action of ATF6 and EZH2 in sensing metabolic stress to boost anti-tumor immunity (2024)

DOI OpenAlex
536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma (2023)

DOI OpenAlex
Abstract LB041: EZH2 and ATF6 sense metabolic stress to balance MHC class I antigen presentation in melanoma (2023)

DOI OpenAlex