B
Brian Koss
Federal Grant PI
Assistant Professor
faculty
Biochemistry & Molecular Biology, College of Medicine
17 h-index
77 pubs
1,956 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Brian Koss is an Assistant Professor in Biochemistry & Molecular Biology at the University of Arkansas for Medical Sciences. His research focuses on understanding the molecular mechanisms that regulate cell survival, apoptosis, and tumorigenesis, with a particular emphasis on cancer. He has received federal funding from the NIH for two grants totaling over $767,000. The first grant, awarded by the National Institute of Dental and Craniofacial Research for $374,185, aims to discover T cell proteome turnover dynamics to overcome the solid tumor microenvironment. The second grant, from the National Cancer Institute for $393,401, focuses on leveraging cancer-evolved resistance mechanisms to enhance EZH2 activity in adoptive T cells, with Koss serving as Co-PI.
Koss's scholarly work includes 75 publications with 1,918 citations and an h-index of 17. His recent publications investigate diverse areas within cancer research, including the role of NEK2 in tumorigenesis, the regulation of DNA damage response pathways, and strategies to restore apoptosis in melanoma cells using CRISPR/dCas9 technology. He also explores the impact of chemical inhibition of DNA-PKcs on T cell function and the influence of resveratrol on antigen presentation in melanoma. His collaborations within the University of Arkansas for Medical Sciences include significant shared publications with Daniel Fil, Lora J. Rogers, Billie Heflin, and Jacob L. Edmondson.
Metrics
- h-index: 17
- Publications: 77
- Citations: 1,956
Selected Publications
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Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function (2026)
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DNA-PKcs controls the cytotoxic T cell response to cancer and transplant allograft through regulating LAT-dependent signaling (2026)
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743 Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function (2025)
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685 EZH2 inhibition impairs CD8+ CAR-T cell persistence (2025)
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691 ATF6 activation promotes ICB response in melanoma (2025)
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762 CD28 costimulation induces PCK2 to support T cell effector function in metabolically hostile environments (2025)
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236 Manipulating the DNA damage response to combat T cell exhaustion and improve immunotherapy response (2025)
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277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion (2025)
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392 Donor-intrinsic proteomic programs shape CAR-T cell persistence across a longitudinal killing assay (2025)
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Comprehensive Analysis of Proteome Turnover Dynamics During T Cell Exhaustion (2025)
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EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma (2025)
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DNA-PKcs Controls the Cytotoxic T-Cell Response to Cancer and Transplant Allograft Through Regulating LAT-Dependent Signaling (2025)
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DNA-PKcs governs LAT-dependent signaling in CD4 <sup>+</sup> and CD8 <sup>+</sup> T cells (2025)
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The Role of CST6 in Immunosuppression in the Multiple Myeloma Microenvironment (2024)
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1132 Enhancing melanoma therapy efficacy by protecting EZH2 activity in T cells (2024)
Federal Grants 3 $1,396,566 total
NIH/National Cancer Institute
Co-PI
May 2026 - Apr 2031
Exploring host GSK3β-53BP1 axis in immune control of solid tumor progression
NIH/National Cancer Institute
Co-PI
Jun 2024 - May 2026
Leveraging cancer-evolved resistance mechanisms to enhance EZH2 activity in adoptive T cells
NIH/National Institute of Dental and Craniofacial Research
Contact PI
Sep 2021 - Aug 2026
Discovering T cell proteome turnover dynamics to overcome the solid tumor microenvironment
Grants & Funding
- Leveraging cancer-evolved resistance mechanisms to enhance EZH2 activity in adoptive T cells NIH/Nat. Cancer Institute Principal Investigator
- Leveraging cancer-evolved resistance mechanisms to enhance EZH2 activity in adoptive T cells NIH/Nat. Cancer Institute Principal Investigator
- Epigenetic regulation of metabolic stress pathways in melanoma infiltrating lymphocytes NIH/Nat. Cancer Institute Principal Investigator
- Leveraging cancer-evolved resistance mechanisms to enhance EZH2 activity in adoptive T cells NIH Co-Principal Investigator
- Discovering T cell proteome turnover dynamics to overcome the solid tumor microenvironment NIH Principal Investigator
- Discovering T cell proteome turnover dynamics to overcome the solid tumor microenvironment NIH/Office of the Director Principal Investigator
- Epigenetic regulation of metabolic stress pathways in melanoma infiltrating lymphocytes NIH/Nat. Cancer Institute Principal Investigator
- DNA-PKcs Regulation of LAT-Mediated Early TCR Signaling in CD4+ and CD8+ T Cells NIH Co-Principal Investigator
Collaboration Network
Top Collaborators
Alan J. Tackett
University of Arkansas for Medical Sciences
24 shared publications
In database
- CRISPR/dCas9-KRAB-Mediated Suppression of S100b Restores p53-Mediated Apoptosis in Melanoma Cells
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- Abstract 1577: Caloric restriction mimetics as adjuvant to immune checkpoint inhibitors for treatment of melanoma
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Abstract 1892: Proteomic interrogation of the metabolic control of MHC class I antigen presentation in metastatic melanoma
Showing 5 of 24 shared publications
Daniel Fil
University of Arkansas for Medical Sciences
20 shared publications
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- 1020 Proteomic analysis of T cell exhaustion unveils differential modulation of the DNA damage response
- 1211 Defining the role of PCK2 in T cell metabolic plasticity in Glioblastoma
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
Showing 5 of 20 shared publications
Sydnye L. Shuttleworth
University of Arkansas for Medical Sciences
16 shared publications
In database
- 1020 Proteomic analysis of T cell exhaustion unveils differential modulation of the DNA damage response
- 1211 Defining the role of PCK2 in T cell metabolic plasticity in Glioblastoma
- 304 Discovering T cell proteome turnover dynamics to enhance persistence in solid tumors
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 929 Proteomic analysis reveals differential modulation of the DNA damage response in exhausted T cells
Showing 5 of 16 shared publications
Lora J. Rogers
University of Arkansas for Medical Sciences
15 shared publications
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- 1020 Proteomic analysis of T cell exhaustion unveils differential modulation of the DNA damage response
- 1211 Defining the role of PCK2 in T cell metabolic plasticity in Glioblastoma
- Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 <sup>+</sup> helper and CD8 <sup>+</sup> effector T cells
- Abstract B015: Racial differences in epigenetic aging and its impact on expression of T-cell inhibitory receptors
Showing 5 of 15 shared publications
Aaron J. Storey
Arkana Laboratories
15 shared publications
In database
- Data from Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma
- Data from Epigenetic Control of <i>Cdkn2a.Arf</i> Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Supplementary Materials from Epigenetic Control of <i>Cdkn2a.Arf</i> Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Supplementary Materials from Epigenetic Control of <i>Cdkn2a.Arf</i> Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Data from Epigenetic Control of <i>Cdkn2a.Arf</i> Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
Showing 5 of 15 shared publications
Jessica L Kelliher
University of Arkansas for Medical Sciences (US)
11 shared publications
- Evolved histone tail regulates 53BP1 recruitment at damaged chromatin
- 1020 Proteomic analysis of T cell exhaustion unveils differential modulation of the DNA damage response
- 304 Discovering T cell proteome turnover dynamics to enhance persistence in solid tumors
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 929 Proteomic analysis reveals differential modulation of the DNA damage response in exhausted T cells
Showing 5 of 11 shared publications
Billie Heflin
University of Arkansas for Medical Sciences
10 shared publications
In database
- CRISPR/dCas9-KRAB-Mediated Suppression of S100b Restores p53-Mediated Apoptosis in Melanoma Cells
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Abstract LB041: EZH2 and ATF6 sense metabolic stress to balance MHC class I antigen presentation in melanoma
- 536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma
Showing 5 of 10 shared publications
Stephanie D. Byrum
St. Jude Children's Research Hospital
10 shared publications
In database
- Data from Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma
- Data from Epigenetic Control of <i>Cdkn2a.Arf</i> Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Supplementary Materials from Epigenetic Control of <i>Cdkn2a.Arf</i> Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Supplementary Materials from Epigenetic Control of <i>Cdkn2a.Arf</i> Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Data from Epigenetic Control of <i>Cdkn2a.Arf</i> Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
Showing 5 of 10 shared publications
Jacob L Edmondson
University of Arkansas for Medical Sciences
10 shared publications
In database
- Role of NEK2 in tumorigenesis and tumor progression
- 536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma
- Abstract 584: Synergistic action of ATF6 and EZH2 in sensing metabolic stress to boost anti-tumor immunity
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 319 Comprehensive analysis of proteome turnover dynamics during T cell exhaustion
Showing 5 of 10 shared publications
Katherine Wallis
University of Arkansas for Medical Sciences
9 shared publications
In database
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- Abstract 1577: Caloric restriction mimetics as adjuvant to immune checkpoint inhibitors for treatment of melanoma
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 929 Proteomic analysis reveals differential modulation of the DNA damage response in exhausted T cells
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
Showing 5 of 9 shared publications
Michael Bauer
University of Arkansas for Medical Sciences
9 shared publications
In database
- 1211 Defining the role of PCK2 in T cell metabolic plasticity in Glioblastoma
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Abstract B015: Racial differences in epigenetic aging and its impact on expression of T-cell inhibitory receptors
- 255 Functional and multi-omic characterization of CAR T cells across healthy donors
- 304 Discovering T cell proteome turnover dynamics to enhance persistence in solid tumors
Showing 5 of 9 shared publications
Erin M. Taylor
9 shared publications
In database
- CRISPR/dCas9-KRAB-Mediated Suppression of S100b Restores p53-Mediated Apoptosis in Melanoma Cells
- Data from Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma
- Data from Epigenetic Control of <i>Cdkn2a.Arf</i> Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Supplementary Materials from Epigenetic Control of <i>Cdkn2a.Arf</i> Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Supplementary Materials from Epigenetic Control of <i>Cdkn2a.Arf</i> Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
Showing 5 of 9 shared publications
Megan R. Reed
University of Arkansas for Medical Sciences
9 shared publications
In database
- CAR-T Therapies in Solid Tumors: Opportunities and Challenges
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Abstract LB041: EZH2 and ATF6 sense metabolic stress to balance MHC class I antigen presentation in melanoma
- 536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma
- Abstract 584: Synergistic action of ATF6 and EZH2 in sensing metabolic stress to boost anti-tumor immunity
Showing 5 of 9 shared publications
Samuel G. Mackintosh
University of Arkansas for Medical Sciences
9 shared publications
In database
- Data from Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma
- Data from Epigenetic Control of <i>Cdkn2a.Arf</i> Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Supplementary Materials from Epigenetic Control of <i>Cdkn2a.Arf</i> Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Supplementary Materials from Epigenetic Control of <i>Cdkn2a.Arf</i> Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Data from Epigenetic Control of <i>Cdkn2a.Arf</i> Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
Showing 5 of 9 shared publications
Bradley D. Shields
8 shared publications
- Data from Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma
- Data from Epigenetic Control of <i>Cdkn2a.Arf</i> Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Supplementary Materials from Epigenetic Control of <i>Cdkn2a.Arf</i> Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Supplementary Materials from Epigenetic Control of <i>Cdkn2a.Arf</i> Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Data from Epigenetic Control of <i>Cdkn2a.Arf</i> Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
Showing 5 of 8 shared publications
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